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News for Healthier Living
Conserved Chromatin Regulators Control the Transcriptional Immune Response to Intracellular Pathogens in Caenorhabditis Elegans
In this study, we show that transcriptional regulators, previously linked to development in Caenorhabditis elegans, also control immune responses. Through forward genetic screens, we found that loss of LIN-15B leads to constitutive activation of Intracellular Pathogen Response (IPR) genes. LIN-15B is functionally associated with the DREAM chromatin remodeling complex, and its loss enhances resistance to intracellular pathogens. This immune response depends on the MES-4 histone methyltransferase. We also discovered that other chromatin regulators, including NuRD and SUMOylation factors, similarly repress IPR gene expression, highlighting a new role in immunity for these conserved regulators of development.
April 8, 2025
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- Make These Scientific Sessions Part of Your Media Coverage
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March 30 2025March 29 2025
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