News for Healthier Living

Muscle Stem Cells Build Resilience but Lose Regenerative Power with Age

* UCLA researchers studying mice discovered that stem cells in aged muscle accumulate a protective protein called NDRG1 that slows their ability to repair tissue but helps the cells survive longer -- revealing that aging may involve a fundamental trade-off between function and resilience. * When scientists blocked NDRG1 in aged mice, muscle stem cells behaved like young cells again and accelerated repair after injury. However, fewer stem cells survived over time, impairing regeneration after repeated injuries. * The findings suggest that simply making old cells act young may not be enough -- future therapies will need to balance both rapid repair capacity and long-term cellular survival to effectively combat age-related decline.

January 29, 2026


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